Prelab 3 reduction of a ketone

Describe the conclusions that you can deduce about the reaction based on your TLC analysis of the reaction i.

Reduction of aldehyde mechanism

Quickly weigh between 0. Occasionally remove the mixture from the hot plate and swirl vigorously. In general, why is re-crystallization of a product preformed? Use the proper arrow drawing convention to show all bond making and bond breaking steps in the reaction. Describe the conclusions that you can deduce about the reaction based on your TLC analysis of the reaction i. It readily reduces aldehydes, ketones, esters, and carboxylic acids to alcohols 1o, 2o, 1o, and 1o respectively and it reduces amides to the corresponding amine. It will readily reduce aldehydes and ketones to primary and secondary alcohols respectively , reduce esters only under select conditions, and is unreactive towards carboxylic acids and amides. Determine the mass and melting point of the product. The contents may need to be warmed to completely dissolve the ketone. In this experiment we will reduce fluorenone to fluorenol using NaBH4 in methanol. Place the magnetic spin vane into your 5 mL conical reaction vial with the point down. NaBH4 absorbs moisture from the atmosphere; therefore, weigh as rapidly albeit accurately as possible. Transfer the product to a labeled product vial and place in the glassware container above your fume hood. After the product has dried, weigh the product, and determine percent yield and melting point of the product.

Using a spotting pipet, spot a sample of the reaction solution before addition of the sodium borohydride in lane 3 designated t0s time zero. After the last spot, develop your two TLC plates using methylene chloride as the developing solvent.

Prelab 3 reduction of a ketone

Pre-Lab Complete the pre-lab assignment in WebAssign. However, the most convenient and least expensive is probably sodium borohydride NaBH4. After the product has dried, weigh the product, and determine percent yield and melting point of the product. Tape a properly labeled TLC plate to the observations section of your lab report. Transfer the crystals to a tared piece of piece of filter paper and place this on a watch glass in your drawer to dry for 24 hours. You are on page 1of 3 Search inside document Reduction of a Ketone Pre Lab Assignment: Complete the pre-lab cover page and develop a procedure. What affect does adding water have on the product solution and why? An approximate mechanism for metal hydride reduction is shown below.

An approximate mechanism for metal hydride reduction is shown below. Include all intermediates, including resonance structures.

Reduction lab report

NaBH4 absorbs moisture from the atmosphere; therefore, weigh as rapidly albeit accurately as possible. It will readily reduce aldehydes and ketones to primary and secondary alcohols respectively , reduce esters only under select conditions, and is unreactive towards carboxylic acids and amides. Trace any spots visualized with a pencil. Tape a properly labeled TLC plate to the observations section of your lab report. Occasionally remove the mixture from the hot plate and swirl vigorously. Related Interests. Show the reactant and product for reduction of benzaldehyde with NaBH4. The contents may need to be warmed to completely dissolve the ketone.

What affect does adding water have on the product solution and why? Mark the two TLC plates in pencil as shown below. How does this compare with your experimental melting point range?

reduction of benzophenone

Each of the four hydrides in NaBH4 is "active" and capable of reducing the carbonyl group of a ketone.

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